Nebenwirkungen

Medically reviewed by Drugs.com. Last updated on Nov 3, 2020.

Dict.cc German-English Dictionary: Translation for Nebenwirkung. English-German online dictionary developed to help you share your knowledge with others. RxISK is a free, independent drug safety website to help you weigh the benefits of any medication against its potential dangers. All drugs have side effects, but people often don’t link the effect they are experiencing to starting, stopping, or changing the dose of a drug. RxISK provides free. Comment by ItsFilko I completed this quest on my level 60 character in order to get the last quest in the chain which rewards 750 Anima. However when levelling my alt I decided to skip the story and just level via dungeons and world quests, I decided to do this quest while in maldraxxas wondering if I can get the 750 Anima at such a low level.

  • Side Effects

For the Consumer

Applies to remdesivir: parenteral powder for injection for iv infusion, parenteral solution concentrate for injection for iv infusion

Side effects include:

Adverse effects reported in ≥5% of patients receiving remdesivir include nausea and increased ALT and AST concentrations.

Phase 3, adaptive, randomized, placebo-controlled trial in hospitalized adults with mild/moderate or severe COVID-19 (NCT04280705; ACTT-1): Serious adverse events reported in 51% of patients in remdesivir group and 57% in placebo group. Adverse events leading to discontinuance of treatment reportedly occurred in 2% of patients receiving remdesivir (seizure, infusion-related reactions, increased aminotransferase concentrations, decreased GFR, acute kidney injury) and 3% of those receiving placebo.

Nebenwirkungen

Phase 3, randomized, open-label trial in hospitalized adults with severe COVID-19 (NCT04292899; GS-US-540-5773; SIMPLE-Severe): Adverse events reported in 70 or 74% of patients who received a 5- or 10-day remdesivir regimen, respectively; serious adverse events (e.g., respiratory distress or failure, septic shock) reported in 21 or 35%, respectively, and grade 3 or greater adverse events reported in 30 or 43%, respectively. Drug discontinued because of adverse events in 4% of patients in 5-day group and 10% of patients in 10-day group. Most common adverse events overall were nausea (10 or 9%), acute respiratory failure (6 or 11%), increased ALT concentrations (6 or 8%), and constipation (7% in both groups),

Phase 3, randomized, open-label trial in hospitalized adults with moderate COVID-19 (NCT04292730; GS-US-540-5774; SIMPLE-Moderate): Adverse events reported in 51 or 59% of patients who received a 5- or 10-day remdesivir regimen, respectively; serious adverse events reported in 5% of patients in both treatment groups, and grade 3 or greater adverse events reported in 11 or 12% of patients receiving 5- or 10-day regimen, respectively. Most common adverse events in patients receiving these respective regimens were nausea (10 or 9%), diarrhea (6 or 5%), hypokalemia (5 or7%), and headache (5% in both treatment groups). Four patients (2%) in 5-day group and 8 patients (4%) in 10-day group discontinued remdesivir due to an adverse event.

For Healthcare Professionals

Applies to remdesivir: intravenous powder for injection, intravenous solution

General

The most common side effect in healthy subjects was increased transaminases. The most common side effects in patients with coronavirus disease 2019 (COVID-19) were nausea, increased AST, and increased ALT.[Ref]

Hepatic

In studies in healthy subjects, increases in ALT, AST, or both in those who received this drug were grade 1 (10%) or grade 2 (4%). In a clinical study of patients with COVID-19, the incidence of at least grade 3 nonserious side effects of increased aminotransferase levels (including ALT, AST, or both) was 4% with this drug compared to 6% with placebo. In a clinical trial in hospitalized patients with severe COVID-19 receiving this drug for 5 or 10 days, any grade (at least 1.25 times the upper limit of normal [1.25 x ULN]) laboratory abnormalities of increased AST and increased ALT were reported in 40% and 42% of patients, respectively; at least grade 3 (at least 5 x ULN) laboratory abnormalities of increased AST and increased ALT were both reported in 7% of patients. In a clinical trial in hospitalized patients with moderate COVID-19 receiving this drug for 5 or 10 days compared to standard of care, any grade laboratory abnormalities of increased AST and increased ALT occurred in 32% and 33% of patients, respectively, receiving this drug and 33% and 39% of patients, respectively, receiving standard of care; at least grade 3 laboratory abnormalities of increased AST and increased ALT occurred in 2% and 3% of patients, respectively, receiving this drug and 6% and 7%, respectively, receiving standard of care.[Ref]

Very common (10% or more): Increased transaminases, increased ALT, increased AST

Common (1% to 10%): Increased aminotransferase levels (including ALT, AST, or both), increased bilirubin

Uncommon (0.1% to 1%): Increased hepatic enzyme, hypertransaminasemia, increased liver function tests[Ref]

Renal

Very common (10% or more): Decreased CrCl (based on Cockcroft-Gault formula; up to 19%), decreased estimated glomerular filtration rate (eGFR; up to 18%), increased creatinine (up to 15%)

Uncommon (0.1% to 1%): Decreased GFR, acute kidney injury[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin (up to 15%), decreased lymphocytes (up to 11%)

Common (1% to 10%): Increased prothrombin time[Ref]

Metabolic

Very common (10% or more): Increased glucose (up to 12%)[Ref]

Gastrointestinal

Common (1% to 10%): Nausea[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Seizure

Frequency not reported: Generalized seizure[Ref]

Dermatologic

Common (1% to 10%): Rash

Frequency not reported: Angioedema[Ref]

Other

Uncommon (0.1% to 1%): Infusion-related reactions, increased blood alkaline phosphatase[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Decreased heart rate[Ref]

Local

Uncommon (0.1% to 1%): Injection site erythema

Frequency not reported: Administration site extravasation[Ref]

Hypersensitivity

Rare (0.01% to 0.1%): Hypersensitivity

Frequency not reported: Anaphylaxis[Ref]

Impfung

References

1. Cerner Multum, Inc. 'Canadian Product Information.' O 0 (2015):

2. Cerner Multum, Inc. 'Australian Product Information.' O 0

3. 'Product Information. Veklury (remdesivir).' Gilead Sciences, Foster City, CA.

4. Cerner Multum, Inc. 'UK Summary of Product Characteristics.' O 0

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about remdesivir

Consumer resources

Other brands:Veklury

Professional resources

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side effects adverse reactions side-effects adverse events adverse effects undesirable effects side effect adverse drug reactions ADRs AEs
toxicity

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die häufigsten Nebenwirkungen265
aufgeführten Nebenwirkungen163
Nebenwirkungen auftreten148
folgenden Nebenwirkungen138
Leider hatte dieses Gegenmittel unerwartete Nebenwirkungen.
Unfortunately, there were some unexpected side effects to this antidote.
Deshalb sollten Sie auf ungewünschte Nebenwirkungen achten.
For this reason, you should watch for undesirable side effects.
Warnungen wegen Herstellungsfehlern oder schwerwiegenden Nebenwirkungen sollten allen Interessierten zugänglich gemacht werden.
Warnings of manufacturing defects or serious adverse reactions should be accessible to all interested persons.
- die Meldung von Nebenwirkungen des Tierarzneimittels.

Nebenwirkungen Pille

- the notification of adverse reactions to the veterinary medicinal product.
Gleichzeitig sollen toxische Nebenwirkungen auf die übrigen Organe herabgesetzt werden.
At the same time, toxic side-effects on the remaining organs are reduced.
Ernsthafte Nebenwirkungen hormonaler Kontrazeptiva sind dagegen sehr selten.
On the other hand, serious side-effects of hormonal contraceptives are rare.
Des Weiteren können alle MS-Therapien Nebenwirkungen haben.
Auch könnten jüngere Patienten zumindest die Nebenwirkungen der Krebsbehandlung besser verkraften.
Moreover, younger patients, at least, can better withstand the side effects of cancer treatment.
Bisher sind nicht annähernd alle Risiken und Nebenwirkungen bekannt.
Currently, by no means all its risks and side effects are known.
Nachteilig ist das Auftreten unerwünschter Nebenwirkungen.
The disadvantage is the occurrence of undesired side effects.
Erforderlich ist eine präzise analytische Untersuchung der Nebenwirkungen.
We need an accurate analytical study assessing the side effects.
Rekombinantes Pseudomonastoxin: Konstruktion eines wirksamen Immunotoxins mit wenigen Nebenwirkungen.
Recombinant pseudomonas exotoxin: construction of an active immunotoxin with low side effects.
Der Referenzmitgliedstaat übernimmt die Verantwortung für die Analyse und Überwachung derartiger Nebenwirkungen.
The reference Member State shall assume the responsibility of analysing and monitoring such adverse reactions.
Beim Neugeborenen wurden keine Nebenwirkungen festgestellt.
No side effects have been noted in the newborn baby.
There are no known side effects of the test.
Weitere häufige Nebenwirkungen sind Erbrechen, Appetitlosigkeit und Fieber.
Other common side effects are vomiting, loss of appetite and fever.
Bei Kindern wurden ähnliche Nebenwirkungen beobachtet.

Grauer Star Op Nebenwirkungen

Die häufigsten Nebenwirkungen von Fertavid sind Reaktionen bzw.
The most common side effects with Fertavid are a reaction and pain at the injection site.
Ähnliche Nebenwirkungen sowie Wachstumsstörungen wurden bei Kindern unter Viraferon beobachtet.
Similar side effects have been seen in children receiving Viraferon, as well as inhibition of growth.
Bei Hühnern und Truthühnern wurden keine Nebenwirkungen durch Dicural festgestellt.
In chickens and turkeys, no side effects from Dicural are known.
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